A second group of people at risk for antimony exposure is patients suffering from schistosomiasis and leishmaniasis. Antimony is usually mixed with other metals such as lead and zinc to form mixtures of metals called alloys. 0. The major toxic side-effects of antimonials as a result of therapy are cardiotoxicity (~9% of patients) and pancreatitis, which is seen commonly in HIV and visceral leishmaniasis co-infections. It has also been listed as a possible human carcinogen by the International Agency for Research on Cancer. The guidelines for maximum permissible levels of antimony in drinking water are as follows: Remove the individual from the toxic environment. 0000002545 00000 n
H��T]o�0}ϯ��I������-�2��QWk7�! In accordance with the diantimony trioxide CSR, the NOAEL of 1686 mg/kg bw/d from a subchronic oral toxicity study in rats is selected as being the most relevant for estimating systemic effects that might be associated with dermal uptake of antimony metal or antimony (III) compounds. Antimony trioxide is used in the production of polyethylene terephthalate (PET) water bottles. 0000001321 00000 n
Despite the fact that large doses work as an emetic, if left untreated, a person may die. H��TMs�0��W�:FA3M;��N�[�dC� �����$ۉ'�dzAB���{oi�-.�&�z!Oe)4W��iM�`"Msh7��8wf|���q�t��q���+V����W�Յ�xh�'�U���5̽?���_�8au���r$. * Exposure to Antimony Trioxidecan irritate the nose, mouth, throat and lungs causing cough, wheezing and/or shortness of breath. The main signs are irritation of the respiratory tract and of the skin and a characteristic pneumoconiosis, which is visible on chest X-rays. 0000007824 00000 n
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The information is not presented with the intention to treat or diagnose any disease or condition. IRIS assessment development process. SAFETY DATA SHEET Creation Date 22-Dec-2009 Revision Date 18-Jan-2018 Revision Number 5 1. Large doses cause vomiting, diarrhea, abdominal discomfort and tingling of the extremities. Antimony trioxide (Sb2O3) is a widely used chemical that can be emitted to soil. It is insoluble in water. Symptoms of Excessive Antimony Exposure and Antimony Toxicity. Exposure to antimony trioxide may increase the risk of cancer. No other human health hazards were identified for antimony(III) oxide, and no risks to human health and the environment were identified from the production and use of antimony trioxide in daily life. 23 0 obj
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The effects are hypothesized to be attributed to inhalation of poorly solubl… 0000002466 00000 n
Antimony trioxide is considered possibly carcinogenic to humans (Group 2B) by the IARC [150] and was recently listed as reasonably anticipated to be a human carcinogen by the NTP [151]. The metal and its compounds can be toxic. Improvements in working conditions have remarkably decreased the incidence of antimony toxicity in the workplace. ; Proposition 65 requires businesses to determine if they must provide a warning about significant exposure to listed chemicals. %%EOF
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�$�*���� �-F�|~9���sƄ�S}�[����Ɯ�(���yNz\F$>&���X&���gXd$8��p4���+7Z��6l[7��$\\����}[�۹���S%�n����Iġ���ݦ�)��jz�ߨU��J0�w������6�E�V$�������W����[��_]�ҁ? Poisoning caused by ingestion of antimony. Identification Product Name Antimony(III) oxide Cat No. Chelation However, these effects are only observed with female rats and after long-term exposure to high dust concentrations. The oxides of arsenic, antimony, and bismuth are comparable in their toxicity, but their volatilities differ widely. Sudden infant death syndrome (SIDS) has also been found to be associated with antimony poisoning. Antimony toxicity occurs either due to occupational exposure or during therapy. Antimony is used as a part of the therapy for these conditions and can sometimes have toxic side effects that lead to pancreatitis and cardiotoxicity. 0000008472 00000 n
A silt-loam soil (pH 7.0, background 0.005 mmol Sb kg−1) was amended with Sb2O3at various concentrations. : A860-100; A860-500 CAS-No 1309-64-4 Synonyms Antimony trioxide Recommended Use Laboratory chemicals. 47 0 obj
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(IARC) (1989) concluded that antimony trioxide is possibly carcinogenic to humans (Group 2B), based on sufficient evidence in animals and inadequate evidence in humans. Chelation therapy with BAL, DMSA, or DMPS has been shown to improve antimony toxicity. endstream
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Toxicity can also result from repeated exposure to antimony in medications, such as tartar emetic (antimony and potassium tartrate), used to induce vomiting and in treatment of helminthic and fungal infestations. Those who are exposed to low doses for over long periods of time, will also show the symptoms of poisoning as mentioned above. Antimony Toxicity 0000003918 00000 n
Over fifty people were "very sick" and treated in hospital after drinking lemonade contaminated with 13 mg/L antimony. [ … 0000006747 00000 n
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